Baneocin is an antibiotic combination for topical use only. It contains two highly effective (bactericidal) antibacterial drugs, neomycin, and bacitracin with a synergistic effect. Bacitracin is active mainly against gram-positive microorganisms, for example, hemolytic streptococcus, staphylococcus, Clostridia, Corynebacterium diphteriae, and also Treponema pallidum and some gram-negative pathogens such as Neisseria and Haemophilus influenzae. Its action also extends to actinomycetes and fusobacteria. Resistance to bacitracin is extremely rare. Neomitsin affects the Gramma monocytogenes, Escherichia coli, and Mycobacterium tuberculosis. Borellia and Leptospira interrogans (L. icterohamororhagicae) is also suppressed by this drug. The combined effect of the two drugs provides a broad antimicrobial spectrum, which, however, does not include pseudomonads, fungi, viruses.