CR500 Topical Gel Monodose 1.5ml 4s

CR500TM is a hydrogel containing peptides and hyaluronic acid with a soothing action that helps prevent and attenuate the physiological degeneration of cartilage in osteoarthritis, thereby protecting against and slowing the progression of joint damage.

FGF-9 is important for the homeostasis of articular cartilage through FGFR3 signaling activation and this mechanism plays a role in the correct formation of the joint space and the inhibition of endochondral ossification. The role of FGF9 in joint development and homeostasis is well supported by the literature, especially its role in controlling chondrocyte development and regulating bone growth, both of which contribute largely to the smooth movement of articulations and thus pain-free movement. Disequilibrium within this system will lead to degraded cartilage and the formation of mineralized “bony” deposits within the articulation leading to pain.

CCN2 is known for its stimulatory effect on the production of extracellular matrix components, indeed disruption of CCN2 leads to defects in collagen III and IV, laminin, and importantly, hyaluronic acid production. The latter of which is crucial in the viscoelasticity of the synovial fluid that lines and lubricates the joints.

Benefits : 

• Prevents and attenuates physiological degeneration of cartilage
• Helps lessen the joint pain and stiffness of osteoarthritis
• Improves joint mobility and helps prevent tightening of the tissues around the joint
• Helps you move pain free
• Helps you remain active without making your symptoms worse
• Offers better control of pain, which may improve how you feel and function physically
• Improves sense of overall well-being with the decrease in the intensity of pain

How to Use : 

• For chronic osteoarthritis, an in situ application of two to four patches of CR500 surrounding the joint in question can be applied 1-2 x week for 1 month, then twice a month for 2-4 months. Several joints can be done at the same time. There is no limit to the amount of monodoses that can be used in one session.
• It is important to cover the gel with an adhesive patch which is provided within the pack. DO NOT USE IT AS A TOPICAL RUB.

General Tips : Make sure the gel does not contact the adhesive sides of the patch. The patch should remain in situ for a minimum of 2.5 hours and optimally for 6-8 hours. There is no limit, the patients can even remove the patch the next day. It is important to tell patients not to get the patch wet once in place. You can wipe the area with alcohol to ensure a clean dry surface. It is important to apply the patch to clean dry skin.